1657
Boston: Measles
1687
Boston: Measles
1690
New York City: Yellow Fever
1713
Boston: Measles
1729
Boston: Measles
1732
-33 Worldwide: Influenza
1738
South Carolina: Smallpox
1739-40
Boston: Measles
1747
Connecticut, New York, Pennsylvania & South Carolina: Measles
1759
North America (areas inhabited by white people): Measles
1761-62
North America & West Indies: Influenza
1772
North America: Measles
1775
North America (especially hard in New England): Epidemic unknown
1775-76
Worldwide: Influenza
1781-82
Worldwide: Influenza (one of the worst flu epidemics)
1788
Philadelphia & New York City: Measles
1793
Vermont: Influenza and a 'putrid fever'
1793
Virginia: Influenza (kills 500 people in 5 counties in 4 weeks)
1793
Philadelphia: Yellow Fever (one of the worst)
1793
Delaware (Dover): 'Extremely fatal' bilious disorder
1793
Pennsylvania (Harrisburg & Middletown): Many unexplained deaths
1794
Philadelphia: Yellow Fever
1796-97
Philadelphia: Yellow Fever
1798
Philadelphia: Yellow Fever (one of the worst)
1803
New York City: Yellow Fever
1820-23
Nationwide: 'Fever' (starts on Schuylkill River in Pennsylvania
& spreads
1831-32
Nationwide: Asiatic Cholera (brought in by English emigrants)
1832
New York City & other major cities: Cholera
1833
Columbus, Ohio: Cholera
1834
New York City: Cholera
1837
Philadelphia: Typhus
1841
Nationwide: Yellow Fever (especially severe in the South)
1847
New Orleans: Yellow Fever
1847-48
Worldwide: Influenza
1848-49
North America: Cholera
1849
New York City: Cholera
1850
Nationwide: Yellow Fever
1850-51
North America: Influenza
1851
Coles Co., Illinois: Cholera
1851
The Great Plains: Cholera
1851
Missouri: Cholera
1852
Nationwide: Yellow Fever (New Orleans: 8,000 die in summer)
1855
Nationwide (many parts): Yellow Fever
1857-59
Worldwide: Influenza (one of the disease's greatest epidemics)
1860-61
Pennsylvania: Smallpox
1865-73
Philadelphia, New York City, Boston, New Orleans, Baltimore, Memphis &
Washington D.C.: A series of recurring epidemics of Smallpox, Cholera,
Typhus, Typhoid, Scarlet Fever, & Yellow Fever
1873-75
North America & Europe: Influenza
1878
New Orleans: Yellow Fever (last great epidemic for this disease)
1885
Plymouth, Pennsylvania: Typhoid
1886
Jacksonville, Florida: Yellow Fever
1918
Worldwide (Pandemic of 1918): Influenza (high point year) - More people were
hospitalized during World War I for Influenza than wounds. U.S. Army
training camps became death camps with up to 80 percent death rates in some
camps.